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KMID : 0355519920160010001
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Korean Journal of Oral Biology
1992 Volume.16 No. 1 p.1 ~ p.12
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Study on the distribution of dental pulp nerve in trigeminal sensory nucleus and analgesic effects of a various drugs on dental pain
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Yoon Soo-Han
Lee Song-Heun
Kim Joong-Soo
Oh Seog-Bae
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Abstract
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EN This experiment was performed to clarify the relay site of primary afferent nerve of dental pulp in trigrminal sensory nucleus complex and to evaluate the analgesic effect of some ions and drugs on dental pain. Deep cavity was prepared on labial surface of lower canine to apply the ions or drugs and ipsilateral inferior alveolar nerve was exposed to record the action potential of single nerve fiber or drugs and ipsilateral inferior alveolar nerve was exposed to record the action potential of single nerve fiber or a pair of wire electrode for record of digastric EMG was inserted into the ipsilateral muscle under genral anesthesia. In order to confirm the neural tracts in trigeminal sensory nucleus, animal was fixed to stereotaxic apparatus and caudal brainstem was exposed. Extracellular neural activity of trigeminal sensory nucleus responded to electrical stimulation of dental pulp was recorded by glass-coated tungsten microelectrode. Tested materials in this experiment were calciun chloride, calcium hydroxide, potassium chloride, eugenol. Zic oxide eugenol and extract of Zingiberis rhizoma and Asiasari rdix. Drug was applied into dental cavity for 15∼45 minutes and neural activity and digastric EMG were recorded before application after application and removalof drugs. Primary afferent of lower canine pulp was projected to all part of trigeminal sensory nucleus. But Aβ-fiber ended in only rostral part of nucleus, Aδ-fiber projected to rostral and caudal part and C-fiber ended in caudal part of nucleus. Calcium chloride increased the threshold intensity of dental pulp significantly but caicium hydroxide showed slight effect on neural activity. Eugenol applied to cavity completely inhibited neural ativity after 45 minutes and decreased digastric EMG. Hypertonic potassium chloride revealed the spontaneous activity of inferior alveolar nerve and minimum inhibitory effect. Extracts of Zingiberis rhizoma and Asiasari radix decreased th elatent period of digastric EMG evoked by noxious stimulation of dental pulp.
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